CovidChloroV1, Main, Exploration, bibRecord, 000719

Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea.

Identifieur interne : 000719 ( Main/Exploration ); précédent : 000718; suivant : 000720

Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea.

Auteurs : Kyungmin Huh [Corée du Sud] ; Wonjun Ji [Corée du Sud] ; Minsun Kang [Corée du Sud] ; Jinwook Hong [Corée du Sud] ; Gi Hwan Bae [Corée du Sud] ; Rugyeom Lee [Corée du Sud] ; Yewon Na [Corée du Sud] ; Jaehun Jung [Corée du Sud]

Source :

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [ 1878-3511 ] ; 2021.

RBID : pubmed:33352326

Descripteurs français

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), Angiotensin Receptor Antagonists (adverse effects), COVID-19 (etiology), Disease Susceptibility (MeSH), Female (MeSH), Humans (MeSH), Hydroxychloroquine (adverse effects), Logistic Models (MeSH), Male (MeSH), Middle Aged (MeSH), Retrospective Studies (MeSH), Risk Factors (MeSH), SARS-CoV-2 (MeSH), Severity of Illness Index (MeSH).
MESH :
- chemical , adverse effects : Angiotensin Receptor Antagonists, Hydroxychloroquine.
- etiology : COVID-19.
- Adult, Aged, Disease Susceptibility, Female, Humans, Logistic Models, Male, Middle Aged, Retrospective Studies, Risk Factors, SARS-CoV-2, Severity of Illness Index.

Abstract

OBJECTIVES

Concerns have been expressed that some drugs may increase susceptibility to SARS-CoV-2 infection. In contrast, other drugs have generated interest as potential therapeutic agents.

METHODS

All adults aged ≥18 years who were tested for COVID-19 were included. Exposure was defined as a prescription of study drugs which would have been continued until 7 days prior to test for COVID-19 or later. The outcome measures were the diagnosis of COVID-19 and severe COVID-19. Disease risk score matching and multiple logistic regression was used.

RESULTS

Matched claims and testing results were available for 219,961 subjects, of whom 7,341 (3.34%) were diagnosed with COVID-19. Patients were matched to 36,705 controls, and the subset of 878 patients of severe COVID-19 also matched with 1,927 mild-to-moderate patients. Angiotensin receptor blockers were not associated with either the diagnosis of COVID-19 (adjusted OR [aOR], 1.02; 95% confidence interval [CI], 0.90-1.15) or severe disease (aOR, 1.11; 95% CI, 0.87-1.42). The use of hydroxychloroquine was not associated with a lower risk for COVID-19 (aOR, 0.94; 95% CI, 0.53-1.66) or severe disease (aOR, 3.51; 95% CI, 0.76-16.22).

CONCLUSIONS

In this national claims data-based case-control study, no commonly prescribed medications were associated with risk of COVID-19 infection or COVID-19 severity.

DOI: 10.1016/j.ijid.2020.12.041
PubMed: 33352326
PubMed Central: PMC7749643

Affiliations:

Corée du Sud

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000621
to stream Main, to step Curation: 000621

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Angiotensin Receptor Antagonists (adverse effects)</term>
<term>COVID-19 (etiology)</term>
<term>Disease Susceptibility (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (adverse effects)</term>
<term>Logistic Models (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>SARS-CoV-2 (MeSH)</term>
<term>Severity of Illness Index (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Antagonistes des récepteurs aux angiotensines (effets indésirables)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hydroxychloroquine (effets indésirables)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Modèles logistiques (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Prédisposition aux maladies (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Études rétrospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Angiotensin Receptor Antagonists</term>
<term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antagonistes des récepteurs aux angiotensines</term>
<term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>COVID-19</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Disease Susceptibility</term>
<term>Female</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>SARS-CoV-2</term>
<term>Severity of Illness Index</term>
</keywords>
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<term>Adulte d'âge moyen</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Modèles logistiques</term>
<term>Mâle</term>
<term>Prédisposition aux maladies</term>
<term>Sujet âgé</term>
<term>Études rétrospectives</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>Concerns have been expressed that some drugs may increase susceptibility to SARS-CoV-2 infection. In contrast, other drugs have generated interest as potential therapeutic agents.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>All adults aged ≥18 years who were tested for COVID-19 were included. Exposure was defined as a prescription of study drugs which would have been continued until 7 days prior to test for COVID-19 or later. The outcome measures were the diagnosis of COVID-19 and severe COVID-19. Disease risk score matching and multiple logistic regression was used.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Matched claims and testing results were available for 219,961 subjects, of whom 7,341 (3.34%) were diagnosed with COVID-19. Patients were matched to 36,705 controls, and the subset of 878 patients of severe COVID-19 also matched with 1,927 mild-to-moderate patients. Angiotensin receptor blockers were not associated with either the diagnosis of COVID-19 (adjusted OR [aOR], 1.02; 95% confidence interval [CI], 0.90-1.15) or severe disease (aOR, 1.11; 95% CI, 0.87-1.42). The use of hydroxychloroquine was not associated with a lower risk for COVID-19 (aOR, 0.94; 95% CI, 0.53-1.66) or severe disease (aOR, 3.51; 95% CI, 0.76-16.22).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>In this national claims data-based case-control study, no commonly prescribed medications were associated with risk of COVID-19 infection or COVID-19 severity.</p>
</div>
</front>
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<ArticleTitle>Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea.</ArticleTitle>
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<Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Concerns have been expressed that some drugs may increase susceptibility to SARS-CoV-2 infection. In contrast, other drugs have generated interest as potential therapeutic agents.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">All adults aged ≥18 years who were tested for COVID-19 were included. Exposure was defined as a prescription of study drugs which would have been continued until 7 days prior to test for COVID-19 or later. The outcome measures were the diagnosis of COVID-19 and severe COVID-19. Disease risk score matching and multiple logistic regression was used.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Matched claims and testing results were available for 219,961 subjects, of whom 7,341 (3.34%) were diagnosed with COVID-19. Patients were matched to 36,705 controls, and the subset of 878 patients of severe COVID-19 also matched with 1,927 mild-to-moderate patients. Angiotensin receptor blockers were not associated with either the diagnosis of COVID-19 (adjusted OR [aOR], 1.02; 95% confidence interval [CI], 0.90-1.15) or severe disease (aOR, 1.11; 95% CI, 0.87-1.42). The use of hydroxychloroquine was not associated with a lower risk for COVID-19 (aOR, 0.94; 95% CI, 0.53-1.66) or severe disease (aOR, 3.51; 95% CI, 0.76-16.22).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In this national claims data-based case-control study, no commonly prescribed medications were associated with risk of COVID-19 infection or COVID-19 severity.</AbstractText>
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</AffiliationInfo>
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</AffiliationInfo>
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<ForeName>Gi Hwan</ForeName>
<Initials>GH</Initials>
<AffiliationInfo><Affiliation>Artificial Intelligence and Big-Data Convergence Center, Gil Medical Center, Gachon University College of Medicine, Incheon, 21565, South Korea.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Lee</LastName>
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<Initials>R</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Na</LastName>
<ForeName>Yewon</ForeName>
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<AffiliationInfo><Affiliation>Artificial Intelligence and Big-Data Convergence Center, Gil Medical Center, Gachon University College of Medicine, Incheon, 21565, South Korea.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Jung</LastName>
<ForeName>Jaehun</ForeName>
<Initials>J</Initials>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004198" MajorTopicYN="N">Disease Susceptibility</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
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<MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
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<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
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<MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="Y">SARS-CoV-2</DescriptorName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">Disease risk score</Keyword>
<Keyword MajorTopicYN="N">Prophylaxis</Keyword>
<Keyword MajorTopicYN="N">South Korea</Keyword>
<Keyword MajorTopicYN="N">Treatment</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>09</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>12</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>12</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>12</Month>
<Day>23</Day>
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<PubMedPubDate PubStatus="medline"><Year>2021</Year>
<Month>4</Month>
<Day>7</Day>
<Hour>6</Hour>
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<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>12</Month>
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<Hour>20</Hour>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">33352326</ArticleId>
<ArticleId IdType="pii">S1201-9712(20)32565-0</ArticleId>
<ArticleId IdType="doi">10.1016/j.ijid.2020.12.041</ArticleId>
<ArticleId IdType="pmc">PMC7749643</ArticleId>
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<affiliations><list><country><li>Corée du Sud</li>
</country>
</list>
<tree><country name="Corée du Sud"><noRegion><name sortKey="Huh, Kyungmin" sort="Huh, Kyungmin" uniqKey="Huh K" first="Kyungmin" last="Huh">Kyungmin Huh</name>
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<name sortKey="Bae, Gi Hwan" sort="Bae, Gi Hwan" uniqKey="Bae G" first="Gi Hwan" last="Bae">Gi Hwan Bae</name>
<name sortKey="Hong, Jinwook" sort="Hong, Jinwook" uniqKey="Hong J" first="Jinwook" last="Hong">Jinwook Hong</name>
<name sortKey="Ji, Wonjun" sort="Ji, Wonjun" uniqKey="Ji W" first="Wonjun" last="Ji">Wonjun Ji</name>
<name sortKey="Jung, Jaehun" sort="Jung, Jaehun" uniqKey="Jung J" first="Jaehun" last="Jung">Jaehun Jung</name>
<name sortKey="Kang, Minsun" sort="Kang, Minsun" uniqKey="Kang M" first="Minsun" last="Kang">Minsun Kang</name>
<name sortKey="Lee, Rugyeom" sort="Lee, Rugyeom" uniqKey="Lee R" first="Rugyeom" last="Lee">Rugyeom Lee</name>
<name sortKey="Na, Yewon" sort="Na, Yewon" uniqKey="Na Y" first="Yewon" last="Na">Yewon Na</name>
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</affiliations>
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   |texte=   Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea.
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	Serveur d'exploration COVID et hydrochloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration COVID et hydrochloroquine

Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea.

Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea.

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